GLP-1 medications have changed what is possible with weight loss. Here is how semaglutide and tirzepatide work, how they differ, and why supervision matters.
What GLP-1 medications actually do
Semaglutide and tirzepatide are GLP-1 based medications that help regulate appetite and blood sugar. In practical terms, they quiet the constant "food noise," slow stomach emptying so you feel full longer, and improve how your body handles insulin. The result for many patients is steadier, more sustainable weight loss than willpower alone can deliver.
The main difference
Semaglutide targets one receptor (GLP-1). Tirzepatide is a dual agonist that targets two (GLP-1 and GIP), which can mean a stronger effect for some patients. Neither is universally "better", the right choice depends on your health history, how your body responds, and your goals. We review all of this at your consultation.
Why medical supervision matters
These are powerful medications, and dosing is titrated slowly to keep you comfortable and minimize side effects like early nausea. Supervised programs also watch the things that make results last: muscle preservation, nutrition, sleep, and stress. At Melange Spa your program starts with labs and a $100 consultation, with $20 follow-ups to adjust your plan.
More than the number on the scale
Beyond weight, GLP-1 therapy is associated with benefits for cardiac and metabolic health. We treat weight loss as part of whole-person care, which is why we pair the medication with guidance on the habits that keep weight off. Learn more on our medical weight loss page.
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Questions
Frequently asked
Semaglutide or tirzepatide, which is right for me?
Both are highly effective. Tirzepatide acts on two receptors and can be stronger for some patients; semaglutide is well established. We recommend the right fit based on your history and goals at your consultation.
How much weight can I expect to lose?
Results vary. Many patients lose a meaningful percentage of body weight over several months, especially when the medication is paired with nutrition and lifestyle support. We do not promise a specific number.
Are there side effects?
Mild nausea or digestive changes are common early and usually settle as the dose is adjusted. We titrate slowly and monitor you throughout.
What does the program cost?
The initial consultation is $100 and follow-ups are $20. Medication cost depends on your plan and is reviewed before you start.
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